When liver glycogen is full… how is glucose metabolism inhibited?

By accumulation of which one?
Fructose-6-phosphate
Glucose-6-phosphate
Glucose-1-phosphate
Pyruvate

If you want to control a metabolic pathway the best sites to do it at at reactions that are irreversible and rate limiting. In the case of humans this mostly is done through inhibition of the enzyme phosphofructokinase 1, which is inhibited by high levels of ATP and citrate (the former implying there’s lots of energy about and the latter coming from the Kreb’s cycle, implying there’s lots of respiration going on), and low pH (this is important to make sure you don’t damage your muscles too badly by doing too much glycolysis with anaerobic respiration, making it too acidic). It is activated by AMP (which is used to make ATP).

Also, glucagon inhibits the enzyme (as glucagon is released during low glucose, when you don’t want to use it all up with glycolysis), by repressing its synthesis.

Pasto’s biology cells met resp details

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